Cardiophile MD Archive

Congenital short QT syndrome is new inherited clinical syndrome which was described by Gussak et al in 2000. (Cardiology. 2000;94:99-102). A gene mutation causing short QT syndrome was first demonstrated by Brugada et al in January 2004. This mutation in HERG (KCNH2) gene was later called as SQT1 and was due to gain in function [...]

Sudden Cardiac Death (SCD) can be defined as natural death from cardiac causes heralded by abrupt loss of consciousness within 1 hour of the onset of an acute change in cardiovascular status. Annual incidence of SCD is about 3 lakhs in the US and 24 million worldwide. Causes Coronary artery disease: 80% CAD is by [...]

  Problems with preventive strategy: 80% occurs at home, only 15% occur in streets or in public places Risk stratification is easy at individual level, but not at a community level Reluctance to start resuscitation due to unwillingness to give mouth to mouth breathing and also the worry about legal problems in case of unwitnessed [...]

What is the role of beta blockers in heart failure? Traditionally it is thought that sympathoadrenergic system activation is compensatory in heart failure. This is true in acute heart failure. But in chronic heart failure, sympathoadrenergic system becomes counter productive and maladaptive. It increases the afterload and myocardial cell necrosis as well down regulation of [...]