Posted by: Johnson Francis on: 07 Mar, 2010
The latest introduction to the congenital long QT syndrome genes is the LQTS 11 (LQT11) gene AKAP9. A-kinase anchor protein 9 (Yotiao) in humans is encoded by the AKAP9 gene. Normally cardiac action potential duration shortens during activation of the sympathetic nervous system. This regulation of the cardiac action potential duration mediated by the beta [...]
Posted by: Johnson Francis on: 26 Jan, 2009
Congenital short QT syndrome is new inherited clinical syndrome which was described by Gussak et al in 2000. (Cardiology. 2000;94:99-102). A gene mutation causing short QT syndrome was first demonstrated by Brugada et al in January 2004. This mutation in HERG (KCNH2) gene was later called as SQT1 and was due to gain in function [...]
Tags:
atrial fibrillation,
causes of short QT interval,
delayed rectifier potassium current,
electrophysiological study,
EP,
genetics of short QT syndrome,
HERG,
hypercalcemia,
hyperthermia,
ICD,
Ik1,
Ikr,
Iks,
implantable cardioverter defibrillator,
KCNH2,
KCNJ2,
KCNQ1,
KvLQT1,
rapid component of delayed rectifier potassium current,
Short QT syndrome,
slow component of the delayed rectifier potassium current,
SQT1,
SQT2,
SQT3,
sudden cardiac death,
tachycardia,
treatment of short QT syndrome,
ventricular fibrillation,
VF
