Posted by: Johnson Francis on: 26 Feb, 2010
Long QT syndromes (LQTS) are a group of inherited arrhythmogenic disorders characterised by prolonged QT interval and life threatening ventricular arrhythmias. The prevalence of long QT syndrome varies from one in five thousand to one in ten thousand in various regions. The initially described syndromes were an autosomal dominant Romano Ward syndrome and the autosomal [...]
Tags:
Andersen syndrome,
CAV3,
caveolin 3,
Implantable defibrillators,
KCNJ2,
Kir2.1,
lqts,
SCNB4,
SIDS,
sudden infant death syndrome,
Timothy syndrome
Posted by: Johnson Francis on: 06 Dec, 2008
10 LQTS genes have been described from 1991 to 2007. LQT1 gene is KCNQ1 and it encodes for alpha (KvLQT1) subunit of the potassium channel conducting the IKs current. IKs is the slow component of the delayed rectifier current, which in turn is the major repolarizing current during phase 3 of the cardiac action potential. [...]
Tags:
Andersen syndrome,
CACNA1c,
CAV3,
caveolin 3,
human Ether-a-go-go Related Gene,
JLN1,
JLN2,
KCNE1,
KCNE2,
KCNH2,
KCNJ2,
KvLQT1,
LQT1,
LQT10,
LQT2,
LQT3,
LQT4,
LQT5,
LQT6,
LQT7,
LQT8,
LQT9,
MinK,
SCN5A,
SCNB4,
SIDS,
sudden infant death syndrome,
Timothy syndrome
