Posted by: Johnson Francis on: 08 Mar, 2010
Inherited Arrhythmias Long QT Syndrome (LQTS 1-12) Brugada Syndrome (BrS 1,2) Catecholaminergic Polymorphic VT (CPVT 1,2) Arrhythmogenic Right Ventricular Cardiomyopathy Short QT Syndrome (SQTS 1-3) Familial Atrial Fibrillation (FAF 1-4) Sinus Node Disease (HCN4, SCN5A) Progressive Cardiac Conduction Defect Congenital Long QT Syndromes LQT1: KCNQ1 (Alpha sub unit) Decrease in IKs (Slow component of delayed [...]
Posted by: Johnson Francis on: 10 Jan, 2010
LQTS In children, there is no particular difference between LQT types regarding the risk of SCD. The risk is more for type 2 after the age of 18 years, while the higher risk in type 3 is after 40 years. Exercise testing has no siginificant role in risk stratification. Aborted SCD is a very important [...]
Posted by: Johnson Francis on: 23 Oct, 2009
SCN5A mutations account for only 20-25% of clinically confirmed cases of Brugada syndrome. One more gene which has been recently associated with Brugada syndrome is: a. SCN4B b. CACNA1c c. GPD1-L d. HCN4 Answer: c Mutation in GPD1-L gene (BrS2)encoding for the protein glycerol-6-phosphate dehydrogenase with loss of function results in reduced outward sodium current [...]
Posted by: Johnson Francis on: 20 Sep, 2009
Epsilon wave is seen in: a. Tachycardiomyopathy b. Arrhythmogenic right ventricular dysplasia c. WPW syndrome d. Brugada syndrome Answer: b Arrhythmogenic right ventricular dysplasia is a condition characterised by fibrofatty degeneration of the right ventricle and recurrent ventricular tachycardia. Epsilon wave is also called “post excitation wave” akin to the prexcitation delta wave seen in [...]
Posted by: Johnson Francis on: 30 Jun, 2009
Patients with Brugada syndrome may have a near normal ECG at times. A drug challenge is needed to unmask the typical features of Brugada syndrome on ECG. Flecainide, a class IC anti arrhythmic drug is often used for this purpose. This test is done only when there is high clinical suspicion of Brugada syndrome due [...]
