Cardiophile MD Archive

Archive for the ‘Multiple Choice Questions’ Category

Smoker’s paradox

Posted by: Johnson Francis on: 10 Jun, 2010

All of the following are true of “smoker’s paradox” except: A. It is a beneficial effect of smoking B. Better outcome following reperfusion strategies C. Likely to undergo reperfusion strategies at a younger age D. Lower co-morbidity Answer: A. It is a beneficial effect of smoking Braunwald’s heart diseases, 8th Edition, Chapter 39, Page 1004.

Nitric oxide synthase

Posted by: Johnson Francis on: 10 Jun, 2010

Endothelial nitric oxide synthase is: A. Type I B. Type II C. Type III D. Type IV Answer: C. Type III Endothelial nitric oxide synthase (eNOS) is Type III. The other types are brain or neuronal NOS (b or nNOS, type I) and inducible NOS (iNOS, type II). All NOS isoforms contain domains for binding [...]

Myocardial postconditioning

Posted by: Johnson Francis on: 10 Jun, 2010

Pathways involved in myocardial postconditioning include all of the following except: A. Reperfusion injury salvage kinase (RISK) pathway B. MEK1/2-ERK pathway C. PI3K-Akt pathway D. GMP Shunt pathway Answer: D. GMP Shunt pathway Ischemic postconditioning, was initially described as a 44% reduction in infarct size with three cycles of 30 second occlusion – re-occlusion during [...]

Lithium and valvular disease in offspring

Posted by: Johnson Francis on: 10 Jun, 2010

Maternal intake of lithium during pregnancy is associated with: A. Tricupsid valve disease B. Mitral valve disease C. Aortic valve disease D. Pulmonary valve disease Answer: A. Tricupsid valve disease Maternal intake of lithium during pregnancy has been associated with Ebstein’s anomaly of tricuspid valve.

Endothelin

Posted by: Johnson Francis on: 10 Jun, 2010

Vasoconstriction by endothelin is mediated by: A. Activation of protein kinase C in vascular smooth muscle B. Prostacyclin activation in vascular smooth muscle C. Synthesis of EDHF in vascular endothelium D. Acetyl choline mediated vasoconstriction Answer: A. Activation of protein kinase C in vascular smooth muscle Endothelins (ET-1, ET-2 and ET-3) are peptide endothelium dependent [...]